Does using a VPN affect my eSIM network?

Using a VPN does not affect your eSIM’s network connectivity.
Turning on a VPN won’t stop your eSIM from working, and it also won’t make an eSIM work outside its supported location. For example, if you’re in Nigeria and turn on a VPN set to the United States, a U.S. local eSIM will still not work because you are not physically in the U.S.
VPNs change your internet location, not your physical network coverage.